Musely Spot Cream Reviews 2023 | Does It Really Work?

I’ve been battling hyperpigmentation for years, so I know how those random dark areas on our skin can cast a looming shadow on her skin goals and confidence. I’m sure you’ve tried every trick in the book to get rid of those spots, from aggressively washing your skin to burning it raw with potent chemical exfoliants. However, it is crucial to understand that conditions such as discoloration and hyperpigmentation necessitate a thorough examination by a doctor and prescription-grade ingredients to be effectively treated. 

Musely Spot Cream Reviews

Seeking medical help for our beauty concerns is not always affordable or accessible, which is where Musely comes in to help. Among their skincare products that address various skincare concerns, Musely Spot Cream is designed to eliminate skin-discoloration issues. It combines the effectiveness of several ingredients to tackle hyperpigmentation at its root. Is it, however, worth a shot? Will it truly dispel years of darkness? Let’s look into it together and read some Musely Spot Cream reviews to find answers to our questions. 

Musely Spot Cream Reviews | Is It Effective? 

Musely is a telemedical service that gives people access to board-certified dermatologists and prescriptions to help them effectively address their skin concerns. This company was founded in Silicon Valley by renowned American entrepreneur Jack Jia. It started as a platform where users could buy products, follow brands, review and rate products, and share tips with friends and followers. In 2019, FaceRx was launched to make prescription skincare more accessible to everyone. 

Cherry, Jack’s wife, battled melasma for years with no effective solution. Despite spending thousands of dollars on laser and over-the-counter treatments, her skin problems persisted until dermatologist Dr. Marie Jhin revealed the secret of prescription skincare one day. Cherry noticed a significant reduction in melasma after only four weeks of following her advice. Jack describes being astounded by her results and knowing he had to share Dr. Jhin’s advice with the rest of the world. 

Musely is now a well-known name in the telemedicine beauty industry, providing affordable, reliable, and effective beauty solutions for various skin concerns such as hyperpigmentation, aging, and more. 

What is Musely Spot Cream? 

Musely Spot Cream is a ‘no-nonsense’ cream that contains multiple science-backed and proven ingredients to combat melasma, dark spots, discoloration, and other skin tone-related issues. This cream is available in four formulations: Erase, Nurture, HQ Free+, and M+, each containing a different blend of ingredients in varying percentages. A board-certified doctor evaluates your medical history and skin concerns to determine your best formulation. 

Musely Spot Cream

This spot cream comes in a 30ml bottle with a pump for easy and sanitary application. Because only a pea-sized amount of this cream is needed for application, it will easily last at least two months. According to Musely, using their products for 6-8 weeks is ideally required to determine their true potency and see visible results. You can also get a refund on any product you are dissatisfied with within 60 days of purchase. 

Who is Musely Spot Cream Ideal for? 

Musely Spot Cream may be a good option if you have any skin-darkening issues listed below.

Melasma: This condition is distinguished by discolored patches darker than your normal skin color. It is symmetrical, with matching marks on both sides of the face, and typically appears on the cheeks, forehead, bridge of the nose, and chin. Treatments that remove the top layers of skin are usually helpful in lightening melasma; however, complete removal is not always possible.


Sun Damage: Months and years of sun exposure, especially without sunscreen, can adversely affect our skin’s complexion. The skin produces melanin, a brown pigment to protect itself from the sun’s rays. The overproduction of this component results in a sun tan, but this pigment often deposits unevenly, resulting in random dark patches on the skin. Some common treatments for sun damage include retinoids, skin-brightening agents, chemical peels, and exfoliants. 

Post-Inflammatory Hyperpigmentation (PIH): Post-inflammatory hyperpigmentation refers to the reaction of skin cells to an injury, damage, or irritation that results in brown/dark brown spots on your skin. Acne, eczema, burns, bumps, allergic reactions, infections, and rashes are common causes of PIH. Ingredients that lighten dark spots, increase skin cell turnover, and remove dead skin cells can help treat this condition. 

dark spots

Dark/ Age Spots: Dark spots are areas with excess melanin production, usually caused by inflammatory skin conditions, sun damage, hormonal changes, wounds, or irritation. Age spots, on the other hand, are dark spots on the skin, typically appearing in areas more exposed to the sun. These spots can be treated using skin-lightening ingredients and procedures. 

Uneven Skin Tone and Discolorations: Uneven skin tone refers to discoloration caused by various factors, including sun exposure, pollution, hormones, and post-inflammatory hyperpigmentation (PIH). Discoloration, on the other hand, refers to the appearance of darker and lighter areas on the skin. Melasma, freckles, and rosacea are examples of common facial discoloration. Exfoliants, chemical peels, and sunscreens, among other things, are adequate to treat and prevent uneven skin tone and discoloration. 

Freckles: Freckles are tan, red, light, or dark brown spots that appear on sun-exposed skin. They are common due to melanin overproduction and pose no medical risk. People with fair skin or red or blond hair are likelier to have freckles because their melanocytes produce more melanin when exposed to sunlight, forming freckles rather than tanning. Freckles are classified into two types: ephelides and solar lentigines, and they can be treated with chemical peels, retinoids, lasers, and cryotherapy. 


Musely Spot Cream Ingredients 

Musely Spot Cream comes in four different formulations, each with a different percentage of ingredients and potency. The key elements of each are briefly mentioned below; let’s look more closely at their functions, efficacy, and benefits. 

Erase (Initial Fill)

  • Hydroquinone 12%
  • Niacinamide 2%
  • Hydrocortisone 1% (for Initial 2-month only)

Hydroquinone is the gold standard for skin lightening. It is a highly effective ingredient for removing melasma, freckles, post-inflammatory hyperpigmentation (PIH), and other discolorations. It essentially beaches your skin by reducing the number of melanocytes (cells that produce melanin), leaving even-toned skin behind. The FDA has approved it as safe and effective. On average, it takes about four weeks for the effects to kick in and months of consistent use to see visible results. 

Niacinamide, known as Niacin or Vitamin B3, is a well-known ingredient with numerous skin benefits. According to research, it improves hydration, reduces dullness, and prevents the signs of aging. When used to treat hyperpigmentation, Niacinamide breaks up existing discoloration while avoiding forming new ones. Based on clinical trials, we can estimate that Niacinamide takes at least 4-8 weeks to improve hyperpigmentation. 

Hydrocortisone is a steroid medication that can help with redness, itching, swelling, and other types of irritation. Furthermore, hydrocortisone (and other steroid creams) change the color of the skin, making them effective at lightening pigmented areas. This occurs because it reduces the activity of pigment cells known as melanocytes. While effective, this component has side effects and should not be used for an extended period. Seek medical advice and use it only under the supervision of a board-certified doctor.  

M+ (Initial Fill) 

  • Hydroquinone 12%
  • Tretinoin 0.05%
  • Niacinamide 2%
  • Hydrocortisone 2.5% (for Initial 2-month only)

Tretinoin is a prescription retinoid that is most commonly used to treat acne, but it can also be used to treat dark spots, photodamage, fine lines, and wrinkles. It lightens the skin by controlling the presence of melanin, stimulates the production of new skin cells, and protects the skin from sun damage. Tretinoin improves hyperpigmentation significantly over six months, according to studies.

Musely spot cream


  • Hydroquinone 6%
  • Vitamin C 1%
  • Niacinamide 2%

Vitamin C is a miracle ingredient that reduces hyperpigmentation, treats sun damage, lessens redness, promotes collagen production, and soothes irritation. It promotes even skin tone by inhibiting melanin synthesis (melanin production) by decreasing tyrosinase activity. It can take up to three months of consistent use to see noticeable results. 

If you’ve heard anything negative about using Vitamin C and Niacinamide, don’t be alarmed to see them in this formulation. Both ingredients are safe to use together and can significantly aid in the fight against pigmentation and dark spot reduction. 

HQ Free+ (Safe for Nursing and Pregnant Women)

  • Tranexamic Acid 6%
  • Azelaic Acid 10%
  • Niacinamide 2%

Tranexamic Acid is a lesser-known ingredient in treating hyperpigmentation, but it is very promising. A 2019 study on participants who used Tranexamic Acid or Hydroquinone for melasma for 12 weeks found that the severity of the condition decreased by 27 percent, roughly the same as it did for those who used Hydroquinone. Furthermore, these participants were more satisfied with Tranexamic Acid because it caused less irritation and side effects. TA can also help to reduce acne-related red spots and reverse sun damage. 

Azelaic Acid is best known for its ability to treat acne and lighten skin discoloration. It acts as a tyrosinase inhibitor (lowers melanin synthesis), reducing the appearance of melasma, dullness, and post-acne pigmentation. It is gentle and non-irritating, making it suitable for long-term use. You may notice visible improvements after 6-8 weeks of using Azelaic Acid, but it takes several months to see significant and desired results. 

The Tranexamic Acid and Niacinamide combination in this formulation enhances their overall effects. This pair is well tolerated by most skin types and can significantly help you combat hyperpigmentation. 

How to Use Musely Spot Cream? 

Musely Spot Cream is a custom blend of potent ingredients, so it should be used correctly to reap the most benefits. 

  1. Begin by cleansing your face with a cleanser to remove dirt, oil, and debris that has clogged your pores. Dry your skin with a towel/tissue. 
  1. Apply a pea-sized amount of Spot Cream to your skin and gently massage it. 
  1. Follow up with applying a moisturizer and a broad-spectrum sunscreen (if used in the morning). 

Note: Musely’s M+ formulation contains highly concentrated ingredients making it only suitable for spot treatment. So, if you’re using this cream, only use it on pigmented areas and not the whole face, as done typically. 

Musely recommends using the cream anywhere from 2-8 weeks to see noticeable results. It is essential to use the cream consistently to see improvement in your skin concerns. You may begin using the cream once every two days and slowly use it daily as your skin adjusts. If you notice any side effects, discontinue its use and try again or seek medical advice. 

Musely spot cream

How to Get Musely Spot Cream? 

The process of purchasing Musely Spot Cream can be categorized into four steps, which are as follows.

  1. Visit the official website (, choose the skin concern you want to target, and add the desired product to your shopping cart. 
  1. After agreeing to telehealth, you will be asked to complete a 3-minute online doctor visit questionnaire. You will also need to upload three photos of your face highlighting the areas of concern as part of this step. 
  1. Following that, a board-certified doctor will thoroughly review your questionnaire and photos before creating a personalized treatment plan. 
  1. At Musely’s pharmacies, the treatments prescribed to you get freshly compounded and sent for delivery to your door. 

The steps above merely provide an overview of the ordering process; to properly understand and complete the ordering process, you can watch this step-by-step tutorial

Musely also provides an automated check-up program known as eNurse to help you during your first 60 days of treatment. This program explains what to expect during your treatment, offers tips for dealing with side effects, and much more. You can access this feature by downloading the Musely app and can learn more about it here

Musely Spot Cream Side Effects 

Musely explains that, as with any prescription product, a small percentage of people may experience side effects such as dryness, redness, peeling, breakouts, warmth, itching, and so on when using the Spot Cream. Let’s look at some ingredients that could cause problems and require caution.

  • Tretinoin is a potent ingredient that, during the first 2-4 weeks of use, may cause redness, dryness, peeling, and worsen existing acne. Furthermore, this ingredient should not be used by pregnant women.
  • Hydroquinone is a skin-lightening agent that could cause skin irritation, burning, stinging, and inflammation. Furthermore, it is not recommended for long-term use because it can cause ochronosis, characterized by the skin’s blue-black or gray-black appearance. 
  • Hydrocortisone is a steroid that can cause skin irritation, rashes, hives, and swelling. This ingredient, like Hydroquinone, is only suitable for short-term use (less than 4 weeks), as prolonged use may cause skin thinness, stretchmarks, swelling, and more
Musely Side Effects

Source: Lauren Erro

Other ingredients are generally well-tolerated, but it is critical to correctly identify your skin type, consider your allergies and medical history, fill out the questionnaire accurately, and perform a patch test beforehand. 

Musely provides assistance through its eNurse feature to properly use its products and manage side effects; however, if you believe you are experiencing severe side effects from any product, you can visit this page for additional help from the company.

Customer Reviews | Musely Spot Cream Before and After 

Musely has a page dedicated to Spot Cream real reviews, where users can read about other people’s experiences and share their own. Many of these reviews include pictures, allowing you to see the progress and improvement brought by the product. 

In addition, I visited a few other websites to learn about other people’s experiences with this product and brand, and this is what I discovered. 

A user named Ashley stated, “My skin developed melasma during my pregnancy. Because I had a difficult pregnancy, I never had the opportunity to care for my skin properly, and there were numerous restrictions on what I could put on my face. After a year or so, I came across Musely and decided to try their Spot Cream, hoping to fade my melasma. I’ve been using it for over 6 months now, and I’m happy to report that it really works. Those stubborn dark spots have vanished, and my skin looks fantastic, boosting my confidence. I recommend that everyone at least try it once.”  

Musely Spot Cream before and after

Many other customers, like Ashley, are pleased with the Musely Spot Cream and its efficacy. Here’s a Reddit thread with people sharing their positive experiences. 

Nonetheless, I also discovered reviews from people dissatisfied with the product, especially with the brand’s customer service. While discussing her experience with Spot Cream in her video, a beauty enthusiast named Lauren mentioned how Musely’s customer service was unsatisfactory when she attempted to repurchase the product. 

Musely Spot Cream Reviews

Similarly, another user stated, “I was prescribed the hydroquinone formulation. I’d never used this ingredient before and wanted to ensure it was safe. I contacted customer service but did not receive prompt assistance, and my order had already shipped while I was trying to clear my doubts. It was a hassle, but thankfully, the product had no side effects, and I could switch to a different formulation the next time.”

Frequently Asked Questions | Musely Spot Cream Reviews

Does Musely really work for brown spots? 

Musely Spot Cream contains scientifically proven ingredients to treat and prevent skin discoloration, including brown spots and blemishes. A formulation will be created for you based on the severity of your concerns and other relevant information. You must use the prescribed treatment correctly and consistently for at least 2-3 months to see visible results. 

How long does it take for Musely Spot Cream to work? 

According to Musely, the Spot Cream takes approximately 2-8 weeks to work. However, the results will vary depending on the severity of your hyperpigmentation, consistency of use, and maintenance. Furthermore, it takes time to effectively treat skin discoloration, so patience is required to truly determine the efficacy of this product. 

Musely Spot Cream

Is Musely Spot Cream legit?

Musely Spot Cream is a legitimate skin-tone correcting cream sold by Musely, a telemedicine service. You can learn more about their service, products, and other information by visiting their official website. 

What happens if you stop using Musely?

Musely Spot Cream effectively treats and prevents hyperpigmentation by inhibiting melanocyte activity. This mechanism persists if you use the cream, so discontinuing use may reintroduce your previous concerns. As a result, maintaining the results for which Musely recommends the Nurture formulation is essential. 


Musely is an affordable and accessible service that offers powerful prescribed solutions for various skin concerns. We can estimate that Spot Cream is potent enough to deliver its claims after examining the formulations and reading numerous positive Musely Spot Cream reviews. If you’ve tried common treatments for hyperpigmentation and nothing is working, you could try this cream. To see promising results, however, it is necessary to use this cream consistently for weeks, attend follow-ups, and practice good skincare and lifestyle habits. 

Leave a Comment